Maternity Departments’ supervisors

This course will enable the supervisor midwife to participate in the research process in midwifery. Contents will focus on problem identification, research design, sampling, data collection and analysis and interpretation of findings. Special attention will be given to develop the ability to criticize research studies in women's and maternal issues and to the selection of a researchable problem and the development of a plan

MIF: Mood Improving/Inhibiting Factor?

Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro- and antidepressant species and discuss the potential implications for therapeutics

Xcast Based Routing Protocol For Push To Talk Application In Mobile Ad Hoc Networks

Mobile ad-hoc networks comprise a type of wireless network that can be easily created without the need for network infrastructure or administration. These networks are organized and administered into temporary and dynamic network topologies. Unfortunately, mobile ad-hoc networks suffer from some limitations related to insufficient bandwidth. The proliferation of new IP Multimedia subsystem services (IMs), such as Push-to-talk (PTT) applications consume large amounts of bandwidth, resulting in degraded QoS performance of mobile ad-hoc networks. In this thesis, a Priority XCAST based routing protocol (P-XCAST) is proposed for mobile ad-hoc networks to minimize bandwidth consumption. P-XCAST is based on demand route requests and route reply mechanisms for every destination in the PXCAST layer. To build the network topology and fill up the route table for nodes, the information in the route table is used to classify the XCAST list of destinations according to similarities on their next hop. Furthermore, P-XCAST is merged with a proposed Group Management algorithm to handle node mobility by classifying nodes into two types: group head and member. The proposed protocol was tested using the GloMoSim network simulator under different network scenarios to investigate Quality of Service (QoS) performance network metrics. P-XCAST performance was better by about 20% than those of other tested routing protocols by supporting of group size up to twenty receivers with an acceptable QoS. Therefore, it can be applied under different network scenarios (static or dynamic). In addition Link throughput and average delay was calculated using queuing network model; as this model is suitable for evaluating the IEEE 802.11 MAC that is used for push to talk applications. The analytical results for link throughput and average delay were used to validate the simulated results

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.

Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes of hypoxia, and other undetermined causes, PH is associated with poor outcomes and a high rate of morbidity. In the neonate, this disease has a similar etiology but is further complicated by the transition to breathing after birth, which requires a reduction in vascular resistance. Persistent pulmonary hypertension of the newborn (PPHN) is one form of PH that is frequently unresponsive to current therapies including inhaled nitric oxide (due to lack of proper absorption and diffusion), and other therapeutics targeting signaling mediators in vascular endothelium and smooth muscle. The need for novel agents, which target distinct pathways in pulmonary hypertension, remains. Herein, we investigated the therapeutic effects of novel muscarinic receptor ligand C1213 in models of PH We demonstrated that via M3 muscarinic receptors, C1213 induced activating- eNOS phosphorylation (serine-1177), which is known to lead to nitric oxide (NO) production in endothelial cells. Using signaling pathway inhibitors, we discovered that AKT and calcium signaling contributed to eNOS phosphorylation induced by C1213. As expected for an eNOS-stimulating agent, in ex vivo and in vivo models, C1213 triggered pulmonary vasodilation and induced both pulmonary artery and systemic blood pressure reductions demonstrating its potential value in PH and PPHN In brief, this proof-of-concept study provides evidence that an M3 muscarinic receptor functionally selective ligand stimulates downstream pathways leading to antihypertensive effects using in vitro, ex vivo, and in vivo models of PH

Using a Mobile Multimedia System to Improve Information Exchange in EMS.

This research uses multiple research methodologies guided by Information Systems Design Theory (ISDT) to design and evaluate a mobile multimedia information system for Emergency Medical Services (EMS). We examined the impact of multimedia information for EMS information exchange and decision-making. A field study was designed and conducted in the Boise, Idaho region for three months to evaluate the system and validate ISDT design propositions. Findings from qualitative analysis illustrated the value of digital images and audio recordings for improving information exchange and augmenting medical decision-making. This paper describes the problem and justification, presents the system design, the pilot test methodology and findings and overall implications and future research directions

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level but also on the behavioral level. Recently, we reported naturally occurring autoantibodies against Aβ (NAbs-Aβ) being reduced in Alzheimer's disease patients. Here, we further investigated their physiological role: in epitope mapping studies, NAbs-Aβ recognized the mid-/C-terminal end of Aβ and preferentially bound to oligomers but failed to bind to monomers/fibrils. NAbs-Aβ were able to interfere with Aβ peptide toxicity, but NAbs-Aβ did not readily clear senile plaques although early fleecy-like plaques were reduced. Administration of NAbs-Aβ in transgenic mice improved the object location memory significantly, almost reaching performance levels of wild-type control mice. These findings suggest a novel physiological mechanism involving NAbs-Aβ to dispose of proteins or peptides that are prone to forming toxic aggregates

Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity

Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop acute kidney injury (AKI) are at increased risk of death. To date there is no effective treatment for AKI or septic AKI. Based on their anti-inflammatory properties, we examined the effects of nicotinic acetylcholine receptor agonists on renal damage using a mouse model of lipopolysaccharide (LPS)-induced AKI where localized LPS promotes inflammation-mediated kidney damage. Administration of nicotine (1 mg/kg) or GTS-21 (4 mg/kg) significantly abrogated renal leukocyte infiltration (by 40%) and attenuated kidney injury. These renoprotective effects were accompanied by reduced systemic and localized kidney inflammation during LPS-induced AKI. Consistent with these observations, nicotinic agonist treatment significantly decreased renal IκBα degradation and NFκB activation during LPS-induced AKI. Treatment of human kidney cells with nicotinic agonists, an NFκB inhibitor (Bay11), or a proteasome inhibitor (MG132) effectively inhibited their inflammatory responses following stimulation with LPS or TNFα. Renal proteasome activity, a major regulator of NFκB-mediated inflammation, was enhanced by approximately 50% during LPS-induced AKI and elevated proteasome activity was significantly blunted by nicotinic agonist administration in vivo. Taken together, our results identify enhanced renal proteasome activity during LPS-induced AKI and the suppression of both proteasome activity and inflammation by nicotinic agonists to attenuate LPS-induced kidney injury